Considerable improvements were achieved when iso-pH solutions were tested, at pH 6.5 and 5.0 (Table 7.23). At pH 5, r2 reached 0.86.

The best correlations were observed under gradient pH and sink conditions (''double-sink'' set at the bottom of Table 7.23), with the donor pH 5 and acceptor pH 7.4 producing r2 0.97. The r2/donor pH plot is shown in Fig. 7.62. The data represented by the solid line corresponds to Pm values (Pe corrected for the

Figure 7.62 Correlation between human jejunal permeabilities [vs. PAMPA (double-sink)] and soy lecithin models under gradient-pH conditions.

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