"All Pe and SD(Pe) are in units of 10 6 cm/s; (nd) = compound not detected in the acceptor compartment.

condition in the acceptor wells. Figure 7.30 shows permeability and membrane retention results for weak-base probes, using the Sigma-Aldrich source of lecithin, with and without sink and 0.5% wt/vol cholesterol. The presence of a sink dramatically increases permeabilities, as indicated in Figure 7.30a. In some cases, further significant increases in permeability were realized by the use of cholesterol, even though its amount was only 0.5%. Only in the diffusion-limited cases (right side of Fig. 7.30a) was there only minimal enhancement due to cholesterol.

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