Intracellular pH Environment

Asokan and Cho [83] reviewed the distribution of pH environments in the cell. Much of what is known in the physiological literature was determined using pH-sensitive fluorescent molecules and specific functional inhibitors. The physiological pH in the cytosol is maintained by plasma membrane-bound H+-ATPases, ion exchangers, as well as the Na+/K+-APTase pumps. Inside the organelles, pH microenvironments are maintained by a balance between ion pumps, leaks, and internal ionic equilibria. Table 2.1 lists the approximate pH values of the various cellular compartments.

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