Nah Nh Antiporters

A key transporter that regulates intracellular pH is the Na+/H+ (NH) antiporter. Unlike the Na+/Ca2+ exchanger, the NH antiporter operates with one-to-one stoichi-ometry and therefore is electroneutral (it is also known as the SL9 family of solute carriers). There are at least eight different isoforms of Na/H exchanger (108). The NH antiporter is localized at the apical membrane of dogfish, frog and bovine RPE (86,88,109). Similar to all Na+/H+ antiporters, it was blocked by amiloride, a potent inhibitor of Na+/H+ antiporters. It normally operates to extrude H+ while permeates Na+. The identity of isoforms of the Na+/H+ antiporter subtypes in RPE are yet to be determined.

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