Np

Deslorelin-NP

Transferrin-NP

Fig. 2. Deslorelin and transferrin functionalizations enhance corneal nanoparticle uptake in bovine ex vivo eye model. A 50 |l drop of 1 mg/ml nanoparticle suspension was topically instilled on an isolated bovine eye maintained at 37°C. After 5 (A) and 60 (B) minutes, particle uptake in corneal epithelium, stroma, endothelium, and aqueous humor was quantified. The data are expressed as mean ± standard deviation for n = 3. The asterisk indicates p < 0.05 compared to NP group and the hash marks indicate p < 0.05 compared to stroma, endothelium or aqueous humor. NP, plain nanoparticles; Deslorelin-NP, deslorelin-conjugated nanoparticles; Transfer-rin-NP, transferrin-conjugated nanoparticles.

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