Dmpd

Table 13.1 Comparison of plasma and serum levels of H2S determined by several commonly used techniques relevance to the cardiovascular system. Male WKY and spontaneous hypertensive rats Male Sprague-Dawley rats I soprenaline-induced myocardial injury Type 1 diabetes Commercial sulfide- Plasma sensitive electrode Commercial sulfide- Plasma sensitive electrode Zinc acetate DMPD Plasma Control rats, 30 M Myocardial injury, 50 Control rats, 65 M Isoprotenolol treated rats, Control rats, 40 Diabetic...

Info

10 Wentworth, P., McDunn, J.E., Wentworth, A.D., Takeuchi, C., Nieva, J., Jones, T., Bautista, C., Ruedi, J.M., Gutierrez, A., Janda, K.D., Babior, B.M., Eschenmoser, A. and Lerner, R.A. (2002) Science, 298 (5601), 2195-2199. 11 Lerner, R.A. and Eschenmoser, A. (2003) Proceedings of the National Academy of Sciences of the United States of America, 100 (6), 3013-3015. 12 Babior, B.M., Takeuchi, C., Ruedi, J., Gutierrez, A. and Wentworth, P. (2003) Proceedings ofthe National Academy ofSciences...

The Mitochondrial Free Radical Theory of Aging

Nowadays, the most supported theory to explain aging is the Mitochondrial Free Radical Theory of Aging (MFRTA). This theory was originally proposed by Denham Harman in 1956 and 1972 3,4 and its original name was the Free Radical Theory of Aging, which with time was refined to the MFRTA. According to this theory, aging is a consequence of the molecular damage caused by free radicals, which are produced during normal metabolism in the mitochondria. Harman's theory obtained the support ofa greater...

Protein Regulation via Sulfination Dependent Proteolysis

A range of proteolytic events have been found to be regulated by cysteine modification. The classic example is the cysteine-dependent autolysis which activates the proteolytic activity of most matrix metalloproteinases (MMPs) 96 . MMPs are expressed in a latent form, and during activation, a conserved cysteine residue within the cysteine switch domain is oxidized to the sulfinic acid form, which exposes the zinc ion and permits autolytic cleavage of the pro-domain, thus enabling proteolysis of...

Multiple Sclerosis

Multiple sclerosis is a disease of the central nervous system (CNS) primarily affecting young adults. The disease usually initially follows a relapsing remitting course, during which symptoms, such as visual disturbances, numbness, weakness or fatigue, appear and then subside. The pathological features of multiple sclerosis include demyelinated lesions, inflammation, axonal loss and glial scarring. Multiple sclerosis has an autoimmune component whereby the body's own immune cells attack the...

List of Authors

Gustavo Barja obtained his PhD in biological sciences from the Complutense University of Madrid in 1981. He continued his scientific research, performing short stays at the Universities of Paris VII (France), UCLA (USA), Brescia (Italy) and ETH (Switzerland). He has dedicated his research activities to the study of free radicals and oxidative stress in animals, focusing on aging and longevity. He is currently full professor of physiology at Complutense University, where he teaches comparative...

Peroxiredoxins

We will now consider the individual players ofthe Prdx-based system. Here, we will begin with Prdx itself. All members ofthe peroxiredoxin family have the structural thioredoxin fold. The fold has a central five-stranded -sheet surrounded by four a-helices -a- -a- -a- - -a . The structural differences between the different members of the Prdx family are in extra domains or extensions outside this basic fold. Peroxiredoxin-1 Prdx 1, UniProt KB accession code Q06830 is also known as thioredoxin...

Atherosclerosis and Cardiovascular Disease

Atherosclerosis and myocardial infarction are leading causes of death worldwide. Atherosclerosis is a chronic inflammatory condition leading to plaque formation. Atherosclerotic plaques are characterized by the subendothelial accumulation of oxidized lipids and inflammatory cells, covered by a fibrous cap of modified smooth muscle cells and their extracellular matrix. As a prelude to atherosclerosis, macrophages internalize oxidatively modified low-density lipoprotein oxLDL and form foam cells,...