There are reports about adjunctive and experimental therapies for ischemia-induced pain. Intravenous adenosine resulted in a reduction of intractable ischemic pain for several hours. A potent, dose-dependent analgesic effect of ketamine in ischemic pain was demonstrated about 10 years ago. However, apparently it has not received further development.
A study of sensory and affective ischemic pain discrimination after inhalation of essential oils led to the conclusion that aromatherapy may not elicit a direct analgesic effect but instead may alter affective appraisal of the experience and consequent retrospective evaluation of treatment-related pain. Hyperbaric oxygenation combined with streptokinase for treatment of arterial thromboembolism of the lower extremity resulted in regression of ischemic pain and prolongation of the survival time of tissues compromised by ischemia. One report suggests that hypnosis may serve as an efficacious adjunct to standard medical care in the management of peripheral arterial occlusive disease.
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