Adjuvant drugs include anti-depressant drugs, traditional anticonvulsant medications, or psychotropic medications. Systemic administration of alpha-2 agonists and NMDA antagonists can help control moderate to severe pain. Many of these medications have significant cardio-respiratory and central effects. Due caution should be exercised in prescribing these medications to the elderly with especial attention given to drug-drug interaction and drug-disease interactions (Jano and Aparasu 2007).
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