Body composition changes quite significantly with aging. There is an overall reduction in lean muscle mass with an incremental increase in total body fat. These changes cause a corresponding reduction in total body water. It has been estimated that body fat increases by approximately 20-40% and body water decreases by 10-15% in old age (McLean and
N. Vadivelu et al. (eds.), Essentials of Pain Management,
DOI 10.1007/978-0-387-87579-8_32, © Springer Science+Business Media, LLC 2011
Couteur 2004). These changes have far reaching consequences on the bioavailability and volumes of distribution of commonly administered drugs (see below).
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