Ketamine is a phencyclidine analog, usually administered intravenously during anesthesia but can be given orally for chronic pain. However, the therapeutic window between the disphoric and hallucinogenic doses and analgesic doses is very small and many patients do not tolerate this agent orally. Newer prospective studies have shown efficacy in the treatment of complex regional pain syndrome (CRPS) (Sigtermans et al. 2009).

Dextromethorphan: (100 mg QID) found in cough syrup usually at 30 mg/tablespoon. Can be compounded by a pharmacist in any dose capsule. Recommended starting dose is 30 mg PO TID.

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