Monoamine Oxidase Inhibitors

Monoamine oxidase inhibitors work by binding to the enzyme monoamine oxidase, thus inhibiting the breakdown of monoamines at the synaptic junction which increases the concentration of the neurotransmitters epinephrine, norepinephrine, and dopamine at various sites in the central nervous system (CNS) and sympathetic storage sites. Therapeutic effect takes 2-4 weeks. Patients prescribed these agents should avoid foods high in tyramine such as cheeses, yeast supplements, and red wines. Meperidine (Demerol®®) must be avoided because of risk of serotonin syndrome and malignant hyperpyrexia.

Isocarboxacid (Marplan®®): 30-50 mg/day (10 mg tablets) Phenelzine (Nardil®®): 45-90 mg/day (15 mg tablets) Tranylcypromine (Parnate®®): 20-60 mg/day (10 mg tablets)

Drug Free Life

Drug Free Life

How To Beat Drugs And Be On Your Way To Full Recovery. In this book, you will learn all about: Background Info On Drugs, Psychological Treatments Statistics, Rehab, Hypnosis and Much MORE.

Get My Free Ebook


Post a comment