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Although less extensively studied than the previously mentioned antidepressants, there are some data suggesting the potential utility of bupropion, nefazodone, trazodone, and mir-tazapine for selected pain states (Ansari 2000, Bendtsen and Jensen 2004, Samborski et al. 2004, Saper et al. 2001, Semenchuk and Davis 2000, Ventafridda et al. 1988). Given the limited number of randomized controlled trials and small sample sizes, definitive statements regarding the utility of these agents and the generalizability of results are not possible.

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