An extensive array of psychopharmacologic agents is available for use in a number of painful conditions. Empirical investigations of the utility of these psychoactive agents as adjuncts in chronic non-malignant pain management have largely focused on antidepressants and anticonvulsants. The following overview will delineate the range of psychopharmacological approaches available to address pain and related psychological comorbidities, although the emphasis will be placed on the role of antidepressants and anticonvulsants.

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