Although fluoxetine (an SSRI) was shown to be as effective as amitriptyline in the control of rheumatic pain (Rani et al. 1996), the SRRIs generally are not effective in pain other than for their antidepressant effects. Yet, Prozac® (Eli Lily, Indianapolis, IN), Zoloft®R (Pfizer, New York, NY), Lexapro®R (Forest Pharmaceuticals, New York, NY), etc. are frequently used as adjuncts to other adjuvants in the treatment of chronic pain conditions. And as indicated previously, bupropion may also be helpful in the polypharmaceutical approach to pain management.
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