YHydroxybutyrate GHB

y-Hydroxybutyrate (GHB) is also known as "liquid ecstasy." It is a popular club drug which acts as a central nervous system (CNS) depressant, causes euphoria, and decreases inhibitions (Hernandez et al. 2005). Also one of the so-called designer drugs, it is often abused by placing it in party drinks to produce sedation and amnesia (Greydanus and Patel 2003). The effects of GHB occur within 10-20 min and can last up to 4 h. The drug is rapidly and completely metabolized in the body to carbon dioxide and water. Large overdoses may result in respiratory depression and death. Cessation from chronic use is associated with withdrawal. GHB was once used as an anesthetic but its usefulness declined as better anesthetic agents with lesser side effects were developed. There are no known antidotes for intoxication with rave or club drugs; treatment would be supportive if such case arises.

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