Locomotor Activity

Two-Way ANOVA revealed no effects of Treatment Group or Treatment Group X Drug interaction on locomotor activity. However, there was a significant main effect of Drug (F[1,56] = 7.94, p < 0.01) due to reduced locomotion in apomorphine-treated animals when compared to vehicle-treated animals (Figure 4). This apomorphine-induced reduction of locomotion was significant for Control and E2/WD treatment groups (both p's < 0.07), but did not attain significance in the E2 group.

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Control E2 E2/WD

Figure 4. Effect of apomorphine on locomotor activity in estradiol-exposed rats. Data are mean (+SEM) photobeam breaks during 15 min of testing for groups of 8-11 animals. * p < 0.05 vs. vehicle within Treatment Group.

Control E2 E2/WD

Figure 4. Effect of apomorphine on locomotor activity in estradiol-exposed rats. Data are mean (+SEM) photobeam breaks during 15 min of testing for groups of 8-11 animals. * p < 0.05 vs. vehicle within Treatment Group.

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