Prepulse Inhibition

Two-way ANOVA revealed no effects of Treatment Group or Treatment Group X Drug interaction on percent PPI. However, there was a significant main effect of Drug (F[1,55] = 21.53, p < 0.001) due to reduced PPI in apomorphine-treated animals when compared to vehicle-treated animals (Figure 2). This apomorphine-induced disruption of PPI was significant for Control and E2 treatment groups (both p's < 0.05), but did not attain significance in the E2/WD group (p = 0.11).

O 50 i2

Vehicle

Apomorpine (0.25 mg/kg)

Vehicle

Apomorpine (0.25 mg/kg)

O 50 i2

Control

E2/WD

Figure 2. Effect of apomorphine on PPI in estradiol-exposed rats. Data are mean (+SEM) percent PPI for groups of 8-11 animals. * p < 0.05 vs. vehicle within Treatment Group.

Control

E2/WD

Figure 2. Effect of apomorphine on PPI in estradiol-exposed rats. Data are mean (+SEM) percent PPI for groups of 8-11 animals. * p < 0.05 vs. vehicle within Treatment Group.

O in

it c in

"cLtO 15

Vehicle

Apomorpine (0.25 mg/kg)

Control E2 E2/WD

Figure 3. Effect of apomorphine on startle amplitude in estradiol-exposed rats. Data are mean (+SEM) startle amplitude (Newtons) for Pulse (Panel A) and Prepulse (Panel B) stimulus trial types for groups of 8-11 animals. * p < 0.01 vs. E2 and E2/WD groups (collapsed across Drug condition).

Control E2 E2/WD

Figure 3. Effect of apomorphine on startle amplitude in estradiol-exposed rats. Data are mean (+SEM) startle amplitude (Newtons) for Pulse (Panel A) and Prepulse (Panel B) stimulus trial types for groups of 8-11 animals. * p < 0.01 vs. E2 and E2/WD groups (collapsed across Drug condition).

0 0

Post a comment