Stereotypy

Two-way ANOVA revealed significant effects of both Treatment Group (F[2,56] = 4.55, p < 0.02) and Drug (F[1,56] = 8.28, p < 0.01) on stereotypic activity (Figure 5).

Vehicle

Apomorpine (0.25 mg/kg)

g 200

Vehicle

Apomorpine (0.25 mg/kg)

g 200

Control E2 E2/WD

Figure 5. Effect of apomorphine on stereotypic movement in estradiol-exposed rats. Data are mean (+SEM) number stereotypic movements during 15 min of testing for groups of 8-11 animals. * p < 0.05 vs. Control group (collapsed across Drug condition). ** p < 0.05 vs. vehicle within Treatment Group.

Control E2 E2/WD

Figure 5. Effect of apomorphine on stereotypic movement in estradiol-exposed rats. Data are mean (+SEM) number stereotypic movements during 15 min of testing for groups of 8-11 animals. * p < 0.05 vs. Control group (collapsed across Drug condition). ** p < 0.05 vs. vehicle within Treatment Group.

Post hoc analyses indicate that stereotypic movements in the E2 group were reduced when compared to the Control group (p = 0.015), and to a lesser extent when compared to E2/WD group (p = 0.078). The effect of Drug was due to a significant apomorphine-induced reduction in stereotypic movement in the Control group (p = 0.01), with a trend toward an apomorphine effect in the E2/WD group (p = 0.075).

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