Figure 17.12 • Comparison of the geometries of oxotremorine and muscarine.
this approach of elevating levels of ACh to treat Alzheimer disease is useful, this belief was highly disputed by many researchers. Nevertheless, oxotremorine, as a cholinergic agonist, facilitates memory storage.40 These findings have served as important leads in the development of agents useful in treating Alzheimer disease. Although it possesses groups that do not occur in other highly active muscarinic agents, oxotremorine's trans conformation shows that distances between possible active centers correspond with (+)-muscarine (Fig. 17.12).41
Arecoline. Arecoline is an alkaloid obtained from the seeds of the betel nut (Areca catechu). For many years, natives of the East Indies have consumed the betel nut as a source of a euphoria-creating substance.
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