Stephen J. Cutler and John H. Block
General Pathways of Drug Metabolism 43
Sites of Drug Biotransformation 45
Role of Cytochrome P450 Monooxygenases in Oxidative Biotransformations 45
Oxidative Reactions 47
Reductive Reactions 78
Hydrolytic Reactions 86
Phase II or Conjugation Reactions 88
Factors Affecting Drug Metabolism 104
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