And Related Organic Compounds

Stephen J. Cutler and John H. Block

General Pathways of Drug Metabolism 43

Sites of Drug Biotransformation 45

Role of Cytochrome P450 Monooxygenases in Oxidative Biotransformations 45

Oxidative Reactions 47

Reductive Reactions 78

Hydrolytic Reactions 86

Phase II or Conjugation Reactions 88

Factors Affecting Drug Metabolism 104

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