Leeches (Hirudo medicinalis) have been used medicinally for centuries to treat injuries in which blood engorges the tissues. The logic behind this is solid: leeches produce an agent known as hirudin that is a potent, specific thrombin inhibitor. Leeches have been used to prevent thrombosis in the microvasculature of reattached digits. Lepirudin (Refludan) is an rDNA-derived protein produced in yeast. It has a molecular mass of approximately 7,000 Da. Lepirudin differs from the natural polypeptide, in that it has an N-terminal leucine instead of isoleucine and is missing a sulfate function at Tyr63.

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Conquering Fear In The 21th Century

Conquering Fear In The 21th Century

The Ultimate Guide To Overcoming Fear And Getting Breakthroughs. Fear is without doubt among the strongest and most influential emotional responses we have, and it may act as both a protective and destructive force depending upon the situation.

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