Indomethacin Double Bond Binding Region

A11-double bond binding region

Tyr-371

A8-double bond binding region

Tyr-371

A11-double bond binding region

A8-double bond binding region

A14-double bond binding region

Extra binding pocket in COX-2

Arg-106

A5-double bond binding region

A14-double bond binding region

Arg-499

Extra binding pocket in COX-2

Arg-106

A5-double bond binding region

Figure 24.15 • Hypothetical binding models of indomethacin to COX-1 and Celecoxib to COX-2. A. Binding of the conventional NSAID, indomethacin, to the active site of COX-1; B. Binding of celecoxib, a selective COX-2 inhibitor to the active site of COX-2 with crystallographic maps suggested by Luong et al. (Flexibility of the NSAID binding site in the structure of human cyclooxygenase-2. Nat. Struct. Biol. 1996;3:927-933)

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