Similar to retinoic acid, the vitamin D receptor (VDR) is a member of the steroid/thyroid hormone superfamily of receptors. These act as ligand-dependent transcription factors that regulate gene expression. In intestine, bone, kidney, and other tissues, calcitriol binds to VDR localized in the cytoplasm, and the complex forms a heterodimer with a retinoid RXR. RXRs are also involved in vitamin A action and the reader is referred to that section for more information. This complex translocates to the nucleus and binds to vitamin D response elements (VDREs) associated with the promoter region of target genes and, together with coactivators, regulates target gene transcription. Over 50 genes have been identified that are controlled by calcitriol.

Conquering Fear In The 21th Century

Conquering Fear In The 21th Century

The Ultimate Guide To Overcoming Fear And Getting Breakthroughs. Fear is without doubt among the strongest and most influential emotional responses we have, and it may act as both a protective and destructive force depending upon the situation.

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