Chapter

Histamine and Antihistaminic Agents 733

Jack DeRuiter

Histamine Chemistry 733

Histamine as a Chemical Messenger 733

Antihistamines 737

Inhibition of Histamine Release: Mast Cell Stabilizers 757

Recent Antihistamine Developments:

the "Dual-Acting" Antihistamines 759

Histamine H2-Antagonists 760

Histamine H3- and H4-Receptor

Ligands 773

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