Chapter

Prostaglandins, Leukotrienes, and Essential Fatty Acids 868

Thomas J. Holmes, Jr.

Essential Fatty Acids 868

History of Eicosanoid Discovery 868

Eicosanoid Biosynthesis 869

Drug Action Mediated by Eicosanoids 872

COX-2 Inhibitors 872

Design of Eicosanoid Drugs 872

Eicosanoid Receptors 875

Commercially Available Essential Fatty Acid

Supplements 875

Eicosanoids Approved for Human

Clinical Use 876

Prostaglandins for Ophthalmic Use 878

Veterinary Uses of Prostanoids 878

Eicosanoids in Clinical Development for Human Treatment 879

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Conquering Fear In The 21th Century

Conquering Fear In The 21th Century

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