Antibacterial Antibiotics 258

Historical Background 258

Current Status 259

Commercial Production 259

Spectrum of Activity 259

Mechanisms of Action 259

Chemical Classification 260

Microbial Resistance 260

^-Lactam Antibiotics 260

The Penicillins 261

^-Lactamase Inhibitors 274

Cephalosporins 278

Monobactams 293

Aminoglycosides 294

Tetracyclines 301

Macrolides 308

Lincomycins 313

Polypeptides 315

Unclassified Antibiotics 320

Newer Antibiotics 324

New Directions in Antibiotic Discovery 326

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