Figure 6.3 • Mechanism of action of 5-fluorocytosine.

Ciclopirox Olamine25

6-Cyclohexyl-1-hydroxyl-4-methyl-2(1H )-pyridinone ethanolamine salt (Loprox) is a broad-spectrum antifungal agent intended only for topical use. It is active against der-matophytes as well as pathogenic yeasts (C. albicans) that are causative agents for superficial fungal infections.

Ciclopirox is considered an agent of choice in the treatment of cutaneous candidiasis, tinea corporis, tinea cruris, tinea pedis, and tinea versicolor. It is a second-line agent for the treatment of onychomycosis (ringworm of the nails). Loprox is formulated as a cream and a lotion, each containing 1% of the water-soluble ethanolamine salt. Ciclopirox is believed to act on cell membranes of susceptible fungi at low concentrations to block the transport of amino acids into the cells. At higher concentrations, membrane integrity is lost, and cellular constituents leak out.

Nucleoside Antifungals


5-Fluorocytosine, 5-FC, 4-amino-5-fluoro-2(1#)-pyrimidi-none, 2-hydroxy-4-amino-5-fluoropyrimidine (Ancobon). 5-Fluorocytosine is an orally active antifungal agent with a very narrow spectrum of activity. It is indicated only for the treatment of serious systemic infections caused by susceptible strains of Candida and Cryptococcus spp.

Was this article helpful?

0 0
Dealing With Asthma Naturally

Dealing With Asthma Naturally

Do You Suffer From ASTHMA Chronic asthma is a paralyzing, suffocating and socially isolating condition that can cause anxiety that can trigger even more attacks. Before you know it you are caught in a vicious cycle Put an end to the dependence on inhalers, buying expensive prescription drugs and avoidance of allergenic situations and animals. Get control of your life again and Deal With Asthma Naturally

Get My Free Ebook

Post a comment