The demethylated metabolite is less anticholinergic, less sedative, and more stimulatory and is a SNERI.31 Consequently, a patient treated with imipramine has two compounds that contribute to activity. Overall, the effect is nonselective 5-HT versus NE reuptake. The activity of desimipramine or norimipramine is terminated by 2-hydroxyla-tion, followed by conjugation and excretion. A second N-demethylation can occur, which in turn is followed by 2-hydroxylation, conjugation, and excretion.

Desipramine Hydrochloride

The structure and salient properties of desipramine hydrochloride, 10,11-dihydro-N-methyl-5H-dibenz[b,f]azepine-5-propanamine monohydrochloride, 5-(3-methylamino-propyl)-10,11-dihydro-5H-dibenz[b,fazepine hydrochloride (Norpramin, Pertofrane), are discussed under the heading, Imipramine. Among tricyclics, desipramine would be considered when few anticholinergic effects or a low level of sedation are important. It is a SNERI.31

How To Reduce Acne Scarring

How To Reduce Acne Scarring

Acne is a name that is famous in its own right, but for all of the wrong reasons. Most teenagers know, and dread, the very word, as it so prevalently wrecks havoc on their faces throughout their adolescent years.

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