Cn

H3C CH3

H3C CH3

Cycloguanil (active metabolite)

Figure 7.9 • Conversion of proguanil to cycloguanil by CYP2C19.

fr900098

Figure 7.10 • Fosmidomycin and a fosmidomycin analog.

elimination half-life of 111 hours). The combination is effective against both erythrocytic and exoerythrocytic Plasmodium. This drug combination is indicated for malaria resistant to chloroquine, halofantrine, mefloquine, and amodiaquine. Its main site is the sporozoite stage (site 1 in Fig. 7.1).

Artemether and Lumefantrine. These two antimalarials interfere with heme metabolism, thereby stopping development of the parasite in the erythrocyte states. Artemether, with its endoperoxide, acts oxidatively and lumefantrine may form a complex with hemin.

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Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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