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Vigabatrin

Ethosuximide

Diazepam

Clonazepam

Diazepam

Clonazepam

VIGABATRIN (SABRIL)

Vigabatrin, a 4-vinyl analog of GABA, produces its pharmacological action by irreversibly blocking GABA catabo-lism catalyzed by GABA-T as discussed earlier. It is marketed in Europe and Canada as an adjunctive treatment of patients with partial seizures, but it has yet to gain FDA approval in the United States even after extensive clinical trials.56 The main concern with this drug is its ability to cause a reversible visual field defect associated with retinal function in the eyes.63

Diazepam (Valium, Diastat)

Diazepam is given orally (Valium) or rectally (Diastat) as an adjunctive treatment in patients with generalized tonic-clonic status epilepticus (i.e., an acute and potentially fatal seizure) or in patients with refractory epilepsy in combination with other AEDs.4 For details on diazepam (Valium), see its discussion under anxiolytics and sedative-hypnotic agents.

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