Crotamiton

N-Ethyl-N-(2-methylphenyl)-2-butenamide, or N-ethyl-o-crotonotoluidide (Eurax), is a colorless, odorless oily liquid. It is virtually insoluble in water but soluble in most organic solvents.

Its antipruritic effect is probably because of a local anesthetic action.

Permethrin

Permethrin is 3-(2,2-Dichloroethenyl)-2,2-dimethyl-cyclopropanecarboxylic acid (3-phenoxyphenyl)methyl ester or 3-(phenoxyphenyl)methyl (±)-cis, trans-3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropanecarboxylate (Nix). This synthetic pyrethrinoid compound is more stable chemically than most natural pyrethrins and is at least as active as an insecticide. Of the four isomers present, the 1(R),trans and 1(R),cis-isomers are primarily responsible for the insecticidal activity. The commercial product is a mixture consisting of 60% trans and 40% cis racemic isomers. It occurs as colorless to pale yellow low-melting crystals or as a pale yellow liquid and is insoluble in water but soluble in most organic solvents.

Crotamiton is available in 10% concentration in a lotion and a cream intended for the topical treatment of scabies.

Permethrin exerts a lethal action against lice, ticks, mites, and fleas. It acts on the nerve cell membranes of the parasites to disrupt sodium channel conductance. It is used as a pediculicide for the treatment of head lice. A single application of a 1% solution effects cures in more than 99% of cases. The most frequent side effect is pruritus, which occurred in about 6% of the patients tested.

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