Muscarinic receptors mediate their effects by activating guanosine triphosphate (GTP)-binding proteins (G proteins). These receptors have seven protein helixes that transcend the plasma membrane, creating four extracellular domains and four intracellular domains (Fig. 17.3). The extracellular domain of the receptor contains the binding site for ACh. The intracellular domain couples with G proteins to initiate biochemical changes that result in pharmacological action from receptor activation.

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Conquering Fear In The 21th Century

Conquering Fear In The 21th Century

The Ultimate Guide To Overcoming Fear And Getting Breakthroughs. Fear is without doubt among the strongest and most influential emotional responses we have, and it may act as both a protective and destructive force depending upon the situation.

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