E

E2020. See Donepezil

EA 713. See Rivastigmine

East African sleeping sickness, 221, 223-224

Echinacea, 962-964, 963/-964f

Echinocanadins, 206

Echothiophate iodide, 572t, 578

Econazole nitrate, 202

Ecstasy. See 2,5-Dimethyl-dicyanoquinonediimine Eculizumab, 658

EDCF. See Endothelium-derived contracting factor

Edecrin. See Ethacrynic acid

Ed-Flex. See Salicylamide

EDRF. See Endothelium-derived relaxing factor

Edrophonium chloride, 572t, 575-576, 601

EES. See Erythromycin ethylsuccinate

Efavirenz, 348

Effexor. See Venlafaxine

Efficacy, of drugs, 581

Eflornithine, 223

Efudex. See 5-Fluorouracil

Ehrlich, Paul, 179

Eicosanoids approved for human use, 876-877 biological activities observed with, 868, 869t biosynthesis of, 869-871, 870/-871/ degradation of, 872, 873/ drug action mediated by, 872 drug design for, 872, 873/, 874t-875t history of, 868-869, 869t receptors of, 875, 876t Elavil. See Amitriptyline hydrochloride Eldepryl. See Selegiline Electromagnetic radiation, 413, 417 Electron capture, 414 Electron volt, 413 Eletriptan, 812t, 813-814, 813/ Eligard. See Leuprolide acetate Ellence. See Epirubicin hydrochloride Elocon. See Mometasone furoate Elspar. See Asparaginase Em. See Estramustine phosphate sodium EMCYT. See Estramustine phosphate sodium Emetine, 222 Empirin. See Aspirin Emtricitabine, 346 E-Mycin. See Erythromycin Enablex. See Darifenacin hydrobromide Enalapril, as prodrug, 5 Enalapril maleate, 610, 611/, 612t Enantiomers, drug metabolism of, 109 Enclomiphene, 833/ Endocannabinoids, 517

Endocrine disorders, nonsteroidal therapies for. See Nonsteroidal therapies for hormone-related disorders Endocytosis, in viral infection, 334 Endometrial cancer, progestins and, 839 Endometriosis, 851 Endomorphins, 779 ß-Endorphin, 778, 893 Endothelin receptor antagonists, 638-639 Endothelium-derived contracting factor (EDCF), 562 Endothelium-derived relaxing factor (EDRF), 562 Enflurane, 712/, 712t, 713, 715 Engerix-B, 145

Enjuvia. See Synthetic conjugated estrogens Enkephalins, 778, 779/, 893 Enoxacin, 208, 208t, 211 Entacapone, 477-478, 524 Entamoeba histolytica, 220 Entocort. See Budesonide Enzactin. See Triacetin Enzyme(s), 880, 885-890, 886/-887/, 888t biotin-dependent, 947, 947t classification of, 887-888 folic acid-dependent, 949, 951t induction, 106-108, 107t inhibition, 108, 108/ rDNA-derived, 908t-909t, 910 recombinant, 142-145

structure-function relationships of, 885-887,

886/-887/ synthesis and secretion of, 887 vitamin B12 and, 953, 953/ zymogens, 887 Eosinophils, 157, 157/ Ephedra, 962, 968-969, 969/ Ephedrine, 30, 533, 544-545, 696/, 969

metabolism of, 83 Epi-ADR. See Epirubicin hydrochloride 4'-Epiadriamycin. See Epirubicin hydrochloride Epilepsy description of, 491 initial drug therapy for, 491^92 prevalence of, 491 seizure classification, 491^92 Epinephrine, 30, 474, 523-524, 524/ in local anesthetics, 724-725 as sympathomimetic, 532-535 Epipodophyllotoxins, 389-391, 390/-391/ Epirubicin hydrochloride, 385, 385/, 388-389 Epitetracyclines, 302, 304 Epitope tagging, 128 Eplerenone, 615, 864, 864/ Epoetin alfa, 908t, 912 Epogen. See Epoetin alfa Epoprostenol. See Prostacyclin Epothilones, 399^00, 399/, 400t Eptifibatide, 629 Equanil. See Meprobamate Equilibrium potential, of neuronal membrane, 719 Equine estrogens, 828-829, 829/ Eqvalan. See Ivermectin

Ergocalciferol, 709, 709/, 923-924, 925/, 927t, 928/

bioactivation of, 924, 926/ Ergosterol in lipid membrane, 193, 194/ photoactivation of, 923, 925/ Ergot derivatives, 475-476 Erlotinib hydrochloride, 403, 404/, 405 ERs. See Estrogen receptors Ertapenem, 325

Erypar. See Erythromycin stearate EryPed. See Erythromycin ethylsuccinate Erythrityl tetranitrate, diluted, 620t, 621 Erythrocin. See Erythromycin Erythrohydrobupropion, 515 Erythromycin, 260t, 308-310 Erythromycin estolate, 311 Erythromycin ethylsuccinate, 311 Erythromycin gluceptate, 311 Erythromycin lactobionate, 311 Erythromycin stearate, 310 Erythromycyclamine, 312-313 Erythropoietin, 908t, 911-912 Erythropoietin alfa, 137 Escitalopram, 31/ Eskazole. See Albendazole Esmolol, 552-553, 553/-554/ Esomeprazole, 765, 767t, 768, 769t Esomeprazole magnesium, 769-770 Essential hypertension, 637-638 Esterified estrogens, 828-829, 829/, 832 Ester local anesthetics, 725-726 Estrace. See Estradiol

17ß-Estradiol, 820/

Estradiol benzoate, 822t

Estramustine phosphate sodium, 407/, 410

Estrogen(s)

aromatase inhibitors, 835-837, 835/ biological activities of, 828 biosynthesis of, 827 endogenous, 827 in HRT, 846-847, 846t metabolism of, 827-828, 828/ in osteoporosis, 705-706 SERMs and antiestrogens, 705, 832-835, 833/ as sex hormones, 827-837, 828/-831/, 833/, 835/ structural classes of, 828-831, 829/-831/ therapeutic uses of, 831 Estrogen receptors (ERs), 825

Estrone, 821/, 827, 829/, 831-832, 835, 835/ Estrumate. See Cloprostenol sodium Eszopiclone, 451 Ethacrynic acid, 25

conjugation of, 97-98 Ethambutol, 215-217 Ethanol, 181-182

as sedative-hypnotics, 455 Ethanolamine antihistamines, 740t, 741-744, 741/ Ethchlorvynol, 455-456 Ether, metabolism of, 75 Ethinyl estradiol, 829/, 832 Ethiodized oil, 433 Ethiodol. See Ethiodized oil Ethionamide, 215-216 Ethisterone, 838/, 838t Ethmozine. See Moricizine Ethopropazine, 460

Ethopropazine hydrochloride, 593, 595 Ethosuximide, 500, 501/ Ethril. See Erythromycin stearate Ethylenediamine antihistamines, 740t, 744-746, 745/ Ethylene oxide, 182

N-Ethylnormorphine, metabolism of, 63, 65 Ethylparaben, 190 Ethynodiol diacetate, 838/, 840 Etidocaine, 728

Etidronate disodium, 706, 707t, 708

Etodolac, 799/, 800

Etomidate, 717

Etonogestrel, 839/, 840

Etoposide, 390-391, 390/

Etretinate, half-life of, 6

Eucatropine hydrochloride, 588-589

Eugenol, 184

Euphoriant-stimulant, 517

Eurax. See Crotamiton

Eutamide, 221

Evamist. See Estradiol

Evista. See Raloxifene

Evoxac. See Cevimeline hydrochloride

Excedrin. See Acetaminophen

Excegran. See Zonisamide

Excitation, of muscle, 622, 622/

Excitatory glutamate-mediated receptors, anticonvulsants and, 494 Excretion, drug distribution and, 4/, 8 Exelderm. See Sulconazole nitrate Exelon. See Rivastigmine Exemestane, 835/, 836 Exenatide, 690/, 691 Exenatide LAR, 692 Exocytosis, viruses, 336

Extended insulin zinc suspension, 901, 901t-902t Extended oral contraceptive therapy, 844 Extended-spectrum penicillins, 267-268 Exubera. See Human insulin, recombinant Ezetimibe, 652

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51 Tips for Dealing with Endometriosis

51 Tips for Dealing with Endometriosis

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