Gallium Radiopharmaceuticals

Gallium Citrate (67Ga). The gallium (III)-citrate complex is formed by adding the required amount of sodium citrate (0.15 M) to gallium (III) chloride and adjusting the pH to 4.5 to 8.0 with sodium hydroxide. Recent studies have proposed a 1:2 gallium:citrate complex.8,9

The patient receives an intravenous injection of 5 to 10 mCi (185-370 MBq) of gallium (67Ga) citrate, and whole-body images are then obtained 24, 48, and 72 hours after injection. Gallium localizes at sites of inflammation or infection as well as various tumors. It is used in clinical practice in the staging and evaluation of recurrence of lymphomas. Gallium localizes normally in the liver and spleen, bone, nasopharynx, lacrimal glands, and breast tissue. There is also some secretion in the bowel; consequently, the patient may require a laxative and/or enemas to evacuate enteric radioactivity prior to the 48-hour image. As more specific radiotracers have been developed, the nonspecific normal localization of gallium radioactivity has limited its clinical use.

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