Dutasteride (Avodart)

Figure 25.24 • Steroid 5a-reductase inhibitors.

bis(trifluoromethyl)phenyl}-3-oxo-4-azaandrost-1-ene-17-carboxamide (Avodart) a newer drug for treating BPH, inhibits both isoforms of the enzyme (Fig. 25.24). Dutasteride bears an aromatic amide at C17, rather than the t-butyl amide seen in finasteride. Both drugs are effective at treating BPH, but a recent retrospective study suggests that rates of acute urinary retention are lower with dutasteride.134 It is not yet known, however, if this reduced urinary retention is a result of the dual inhibition nature of dutasteride. Dutasteride inhibits 5a--reductase by the same mechanism as finasteride and has a long terminal elimination half-life, which is approximately 5 weeks at steady state. In addition to the treatment of BPH, dutasteride is being investigated for its ability to delay the progression of

Was this article helpful?

0 0
Reducing Blood Pressure Naturally

Reducing Blood Pressure Naturally

Do You Suffer From High Blood Pressure? Do You Feel Like This Silent Killer Might Be Stalking You? Have you been diagnosed or pre-hypertension and hypertension? Then JOIN THE CROWD Nearly 1 in 3 adults in the United States suffer from High Blood Pressure and only 1 in 3 adults are actually aware that they have it.

Get My Free Ebook

Post a comment