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Benazepril Hydrochloride. Benazepril hydrochloride, (3S)-3-[[(1 S)-1-carbethoxy-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid 3-ethyl ester hydrochloride (Lotensin), is metabolized rapidly to the active diacid benazaprilat. As with the ACE prodrugs, no mutagenicity has been found, even though these drugs cross the placenta.

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Benazepril (Lotensin)

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Benazepril (Lotensin)

Quinapril Hydrochloride. Quinapril hydrochloride, (S)-[(S)-N- [(S)21-carboxy3-phenylpropyl]alanyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid 1-ethyl ester hy-drochloride (Acuretic), forms the diacid quinaprilate in the body. It is more potent than captopril and equipotent to the active form of enalapril.

Quinapril (Accupril)

Ramipril. Ramipril, (2S, 3aS, 6aS)-1-[(S)-N-[(S)-1-car-boxy-3-phenylpropyl]alanyl]octahydrocyclopenta[b ]-pyrrole-2-carboxylic acid 1-ethyl ester (Altace), is hydrolyzed to ramiprilat, its active diacid form, faster than enalapril is hydrolyzed to its active diacid form. Peak serum concentrations from a single oral dose are achieved between 1.5 and 3 hours. The ramiprilate formed completely

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