Benazepril Hydrochloride. Benazepril hydrochloride, (3S)-3-[[(1 S)-1-carbethoxy-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid 3-ethyl ester hydrochloride (Lotensin), is metabolized rapidly to the active diacid benazaprilat. As with the ACE prodrugs, no mutagenicity has been found, even though these drugs cross the placenta.
Quinapril Hydrochloride. Quinapril hydrochloride, (S)-[(S)-N- [(S)21-carboxy3-phenylpropyl]alanyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid 1-ethyl ester hy-drochloride (Acuretic), forms the diacid quinaprilate in the body. It is more potent than captopril and equipotent to the active form of enalapril.
Ramipril. Ramipril, (2S, 3aS, 6aS)-1-[(S)-N-[(S)-1-car-boxy-3-phenylpropyl]alanyl]octahydrocyclopenta[b ]-pyrrole-2-carboxylic acid 1-ethyl ester (Altace), is hydrolyzed to ramiprilat, its active diacid form, faster than enalapril is hydrolyzed to its active diacid form. Peak serum concentrations from a single oral dose are achieved between 1.5 and 3 hours. The ramiprilate formed completely
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