Benazepril Hydrochloride. Benazepril hydrochloride, (3S)-3-[[(1 S)-1-carbethoxy-3-phenylpropyl]amino]-2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetic acid 3-ethyl ester hydrochloride (Lotensin), is metabolized rapidly to the active diacid benazaprilat. As with the ACE prodrugs, no mutagenicity has been found, even though these drugs cross the placenta.
Quinapril Hydrochloride. Quinapril hydrochloride, (S)-[(S)-N- [(S)21-carboxy3-phenylpropyl]alanyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid 1-ethyl ester hy-drochloride (Acuretic), forms the diacid quinaprilate in the body. It is more potent than captopril and equipotent to the active form of enalapril.
Ramipril. Ramipril, (2S, 3aS, 6aS)-1-[(S)-N-[(S)-1-car-boxy-3-phenylpropyl]alanyl]octahydrocyclopenta[b ]-pyrrole-2-carboxylic acid 1-ethyl ester (Altace), is hydrolyzed to ramiprilat, its active diacid form, faster than enalapril is hydrolyzed to its active diacid form. Peak serum concentrations from a single oral dose are achieved between 1.5 and 3 hours. The ramiprilate formed completely
Was this article helpful?
A Guide to Natural Sleep Remedies. Many of us experience the occasional night of sleeplessness without any consequences. It is when the occasional night here and there becomes a pattern of several nights in arow that you are faced with a sleeping problem. Repeated loss of sleep affects all areas of your life The physical, the mental, and theemotional. Sleep deprivation can affect your overall daily performance and may even havean effecton your personality.