Hn Nh

Lys O BCCP Figure 28.40 • Coenzyme form of biotin.

the case of two identified genetic disorders. Holocarbo-xylase deficiency is a genetic disorder of biotin-(propionyl-CoA-carboxylase [ATP-hydrolysing]) ligase, the enzyme responsible for the terminal step incorporating biotin into the apoenzyme. Biotinidase (EC 3.5.1.12) deficiency is a genetic disorder of the amidase that releases biotin from the apoenzyme and allows it to be recycled. Both of these lead to multiple carboxylase deficiency (MCD), a condition marked by decreased activity of all biotin-dependent car-boxylases and both respond, at least partially, to large doses of biotin.197 The symptoms of biotin deficiency include dermatitis, conjunctivitis, alopecia, and CNS abnormalities including behavioral, developmental, and psychological effects.198

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Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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