Lubiprostone. This product is marketed as Amitiza by Sucampo Pharmaceuticals, Inc. and Takeda Pharmaceuticals America, Inc. to relieve chronic idiopathic constipation in adults. The recommended oral dosage is 24 /g 2 times a day with food. Precautions and side effects are similar to those for other prostaglandin-derived products.

Prostacyclin (PGI2). Marketed as the sodium salt (epoprostenol; Flolan by GlaxoSmithKline), this product is administered by continuous infusion of a recently prepared solution (within 48 hours) for the treatment of primary pulmonary hypertension (PPH). The chemical stability of this compound in aqueous solution is limited, and the biological half-life is less than 6 minutes. The potent va-sodilatory, platelet antiaggregatory effect, and vascular smooth muscle antiproliferatory effect of this naturally occurring eicosanoid produce a dramatic but short-lived therapeutic effect in PPH patients. Because continuous uninterrupted administration of the drug by portable infusion pump is necessary to prevent symptoms of rebound pulmonary hypertension, distribution of this product is restricted.28

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