The antiviral use of cytarabine is in the treatment of herpes zoster (shingles), herpetic keratitis, and viral infections that resist idoxuridine. Cytarabine is usually administered topically. Toxicity occurs on bone marrow, the gastrointestinal (GI) tract, and the kidneys.
Trifluridine, 5-trifluoromethyl-29-deoxyuridine (Viroptic), is a fluorinated pyrimidine nucleoside that demonstrates in vitro inhibitory activity against HSV-1 and HSV-2, CMV, vaccinia, and some adenoviruses.33 Trifluridine possesses a trifluoromethyl group instead of an iodine atom at the 5-position of the pyrimidine ring. The van der Waals radius of the trifluoromethyl group is 2.44 A, somewhat larger than that of the iodine atom.
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