High doses of folic acid are rather nontoxic; however, at least one study has shown that 15 mg/day for 1 month can result in gastrointestinal disturbances (including anorexia, nausea, and pain) and CNS effects (including sleep disturbances, vivid dreams, malaise, irritability, and increased ex-citability).213 The primary danger of excessive folate intake is the masking of vitamin B12 deficiency. Folic acid can correct the anemia caused by vitamin B12 deficiency, but it has no effect on the neurological damage. The potential for high doses of folic acid to mask B12 deficiency explains why large daily doses of folic acid are best avoided in the general population.
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