High doses of vitamin C can lead to renal, bone, hematolog-ical, and gastrointestinal effects.46 Renal calculi because of oxalate or urate result from enhanced renal excretion of these compounds in the presence of high doses of vitamin C. Increased release of calcium and phosphorus from bone have been observed. Hematological effects include increased absorption of nonheme iron without significant increases in total body iron stores. Diarrhea, likely resulting from an osmotic effect, has been reported following large doses, and ascorbic acid tablets that lodge in the esophagus can cause local erosion. Finally, ascorbic acid has been shown to interfere with several colorimetric redox assays because of its ability to act as a reducing agent.

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Conquering Fear In The 21th Century

Conquering Fear In The 21th Century

The Ultimate Guide To Overcoming Fear And Getting Breakthroughs. Fear is without doubt among the strongest and most influential emotional responses we have, and it may act as both a protective and destructive force depending upon the situation.

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