Ifn

2'5'-Oligoadenylate synthetase ATP-^2'5'-OA-► Ribonuclease R

Hydrolyze Viral RNA Figure 9.4 • IFNs predominantly inhibit protein synthesis.

O NUCLEOSIDE ANTIMETABOLITES: INHIBITING VIRAL REPLICATION

Inhibitors of DNA Polymerase

Idoxuridine

Idoxuridine, 5-iodo-2'-deoxyuridine (Stoxil, Herplex), was introduced in 1963 for the treatment of herpes simplex keratitis.32 The drug is an iodinated analog of thymidine that inhibits replication of several DNA viruses in vitro. The susceptible viruses include the herpesviruses and poxviruses (vaccinia).

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Healthy Sleep

Healthy Sleep

A Guide to Natural Sleep Remedies. Many of us experience the occasional night of sleeplessness without any consequences. It is when the occasional night here and there becomes a pattern of several nights in arow that you are faced with a sleeping problem. Repeated loss of sleep affects all areas of your life The physical, the mental, and theemotional. Sleep deprivation can affect your overall daily performance and may even havean effecton your personality.

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