Ifn

2'5'-Oligoadenylate synthetase ATP-^2'5'-OA-► Ribonuclease R

Hydrolyze Viral RNA Figure 9.4 • IFNs predominantly inhibit protein synthesis.

O NUCLEOSIDE ANTIMETABOLITES: INHIBITING VIRAL REPLICATION

Inhibitors of DNA Polymerase

Idoxuridine

Idoxuridine, 5-iodo-2'-deoxyuridine (Stoxil, Herplex), was introduced in 1963 for the treatment of herpes simplex keratitis.32 The drug is an iodinated analog of thymidine that inhibits replication of several DNA viruses in vitro. The susceptible viruses include the herpesviruses and poxviruses (vaccinia).

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