Ifn

2'5'-Oligoadenylate synthetase ATP-^2'5'-OA-► Ribonuclease R

Hydrolyze Viral RNA Figure 9.4 • IFNs predominantly inhibit protein synthesis.

O NUCLEOSIDE ANTIMETABOLITES: INHIBITING VIRAL REPLICATION

Inhibitors of DNA Polymerase

Idoxuridine

Idoxuridine, 5-iodo-2'-deoxyuridine (Stoxil, Herplex), was introduced in 1963 for the treatment of herpes simplex keratitis.32 The drug is an iodinated analog of thymidine that inhibits replication of several DNA viruses in vitro. The susceptible viruses include the herpesviruses and poxviruses (vaccinia).

Was this article helpful?

0 0
Conquering Fear In The 21th Century

Conquering Fear In The 21th Century

The Ultimate Guide To Overcoming Fear And Getting Breakthroughs. Fear is without doubt among the strongest and most influential emotional responses we have, and it may act as both a protective and destructive force depending upon the situation.

Get My Free Ebook


Post a comment