Info
- VCH_
Figure 20.9 • Repaglinide solution ionization. The proton dissociation microconstants combine to account for the observed macro pKa values, as well as the lipid/aqueous phase partitioning characteristics.12
TABLE 20.4 Glinides Marketed in the United States3
Protein Volume of Lipid Partitioning Biotrans- Oral Bio- Dosage Forms
Drug Binding Distribution Character formation availability Elimination and Dose Range
TABLE 20.4 Glinides Marketed in the United States3
Protein Volume of Lipid Partitioning Biotrans- Oral Bio- Dosage Forms
Drug Binding Distribution Character formation availability Elimination and Dose Range
|
Repaglinide |
98%, Vss = 31 L |
Log D7.4 ~2.6c |
Extensive 56%d |
8% urine as |
Tablets |
|
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