Info

VCH_

Figure 20.9 • Repaglinide solution ionization. The proton dissociation microconstants combine to account for the observed macro pKa values, as well as the lipid/aqueous phase partitioning characteristics.12

TABLE 20.4 Glinides Marketed in the United States3

Protein Volume of Lipid Partitioning Biotrans- Oral Bio- Dosage Forms

Drug Binding Distribution Character formation availability Elimination and Dose Range

TABLE 20.4 Glinides Marketed in the United States3

Protein Volume of Lipid Partitioning Biotrans- Oral Bio- Dosage Forms

Drug Binding Distribution Character formation availability Elimination and Dose Range

Repaglinide

98%, Vss = 31 L

Log D7.4 ~2.6c

Extensive 56%d

8% urine as

Tablets

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