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Adapted from Rodig, O.R.: In Burger, A. (ed.). Medicinal Chemistry, Part 2, 3rd ed. New York, Wiley-Interscience, 1970. Used with permission. a+, retention; —, excretion.

Adapted from Rodig, O.R.: In Burger, A. (ed.). Medicinal Chemistry, Part 2, 3rd ed. New York, Wiley-Interscience, 1970. Used with permission. a+, retention; —, excretion.

Table 25.6 summarizes the relative effects of various substituents seen in commercially available products on salt retention and GC activity. The salt-retaining actions are approximately additive. For example, the 3 + increase in salt retention of a 9a-fluoro group can be eliminated by the 3-decrease of a 6a-methyl.

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