Info

treatment.270

Table 24.2 summarizes the pharmacokinetic properties of clinically available triptans that contributes to their efficacy, safety, and tolerability.259,262,270-274 A quick glance at their chemical structures (see Fig. 24.27) reveals two general structural types, which might provide insights for assessing some of these differences.

The 3-alkylaminoethyl containing triptans (sumatriptan, zolmitriptan, rizatriptan, and almotriptan) are substrates for the hepatic monoamine oxidase type A (MAO-A) because

TABLE 24.2 Pharmacokinetic Properties of the Triptansa

Bioavailability Onset Time Plasma Metabolizing Drug % CNS

Drug Trade Name Oral (%) (min) Half-life (h) Enzymea,b Interactions Side Effects

TABLE 24.2 Pharmacokinetic Properties of the Triptansa

Bioavailability Onset Time Plasma Metabolizing Drug % CNS

Drug Trade Name Oral (%) (min) Half-life (h) Enzymea,b Interactions Side Effects

Sumitriptan

Imitrex Imigrain

Was this article helpful?

0 0
Conquering Fear In The 21th Century

Conquering Fear In The 21th Century

The Ultimate Guide To Overcoming Fear And Getting Breakthroughs. Fear is without doubt among the strongest and most influential emotional responses we have, and it may act as both a protective and destructive force depending upon the situation.

Get My Free Ebook


Post a comment