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treatment.270

Table 24.2 summarizes the pharmacokinetic properties of clinically available triptans that contributes to their efficacy, safety, and tolerability.259,262,270-274 A quick glance at their chemical structures (see Fig. 24.27) reveals two general structural types, which might provide insights for assessing some of these differences.

The 3-alkylaminoethyl containing triptans (sumatriptan, zolmitriptan, rizatriptan, and almotriptan) are substrates for the hepatic monoamine oxidase type A (MAO-A) because

TABLE 24.2 Pharmacokinetic Properties of the Triptansa

Bioavailability Onset Time Plasma Metabolizing Drug % CNS

Drug Trade Name Oral (%) (min) Half-life (h) Enzymea,b Interactions Side Effects

TABLE 24.2 Pharmacokinetic Properties of the Triptansa

Bioavailability Onset Time Plasma Metabolizing Drug % CNS

Drug Trade Name Oral (%) (min) Half-life (h) Enzymea,b Interactions Side Effects

Sumitriptan

Imitrex Imigrain

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