Ketotifen fumarate, 4-(1-methyl-4-piperidylidene)-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-10(9H)-one hydrogen fumarate (Zaditor), is a fine crystalline powder. Ketotifen is a ketothiophene isostere analog of the diben-zocycloheptane antihistamines. The solution contains 0.345 mg of ketotifen fumarate, which is equivalent to 0.25 mg of ketotifen. The solution also contains the preservative benzalkonium chloride (0.01%) as well as glycerol, sodium hydroxide and/or hydrochloric acid (to adjust pH), and purified water. It has a pH of 4.4 to 5.8 and an osmolality of 210 to 300 mOsm/kg.
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