Blood Pressure In Pharmaceutical Chemistry

Hydralazine (Apresoline)

Sodium Nitroprusside, USP. Sodium nitroprusside, sodium nitroferricyanide, disodium pentacyanonitrosylfer-rate(2) Na2[Fe(CN)5NO] (Nipride, Nitropress), is one of the most potent blood pressure-lowering drugs. Its use is limited to hypertensive emergencies because of its short duration of action. The effectiveness of sodium nitroprusside as an antihypertensive has been known since 1928, but not until 1955 was its efficacy as a drug established.62 The drug differs from other vasodilators, in that vasodilation occurs in both venous and arterial vascular beds. Sodium nitroprus-side is a reddish brown water-soluble powder that is decomposed by light when in solution. The hypotensive effect of the chemical is a result of the formation of NO in situ (discussed under the heading, "Nitrovasodilators"), elevating cellular levels of cGMP. Sodium nitroprusside is metabolized by the liver, yielding thiocyanate. Because thiocyanate is excreted by the kidneys, patients with impaired renal function may suffer thiocyanate toxicity.

Na2[Fe(CN)5NO] . 2H20 Sodium Nitroprusside

Hydralazine Metabolism
Figure 19.15 • Metabolism of hydralazine hydrochloride.

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Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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