It was thought originally that cholecystokinin and pancreozymin were two different hormones. Cholecystokinin was thought to be responsible for contraction of the gallbladder, whereas pancreozymin was believed to induce secretion of pancreatic enzymes. It is now clear that both actions are caused by a single 33-residue polypeptide, referred to as cholecystokinin-pancreozymin (CCK-PZ). CCK-PZ is secreted in the blood in response to the presence of food in the duodenum, especially long-chain fatty acids. The five COOH-terminal amino acid residues are identical with those in gastrin. The COOH-terminal octapeptide retains full activity of the parent hormone.




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