N

retains high binding affinity to the receptor, but no intrinsic activity. It is used to reverse the respiratory depressant effects of opioid overdoses.

Naloxone is administered intravenously with an onset of action within 2 minutes. Because it is competing with the opioid for the receptor sites, the dose and frequency of administration will depend on the amount and type of narcotic being antagonized. Overdoses of long-acting opioids (methadone) may require multiple IV doses of naloxone or continuous infusions. Neonates born to opioid-exposed mothers may be given IV naloxone at birth to reverse the effects of opiates.

Very few metabolism studies on naloxone have been conducted, although the major metabolite found in the urine is naloxone-3-glucuronide.121,122

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Free Yourself from Panic Attacks

Free Yourself from Panic Attacks

With all the stresses and strains of modern living, panic attacks are become a common problem for many people. Panic attacks occur when the pressure we are living under starts to creep up and overwhelm us. Often it's a result of running on the treadmill of life and forgetting to watch the signs and symptoms of the effects of excessive stress on our bodies. Thankfully panic attacks are very treatable. Often it is just a matter of learning to recognize the symptoms and learn simple but effective techniques that help you release yourself from the crippling effects a panic attack can bring.

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