retains high binding affinity to the receptor, but no intrinsic activity. It is used to reverse the respiratory depressant effects of opioid overdoses.
Naloxone is administered intravenously with an onset of action within 2 minutes. Because it is competing with the opioid for the receptor sites, the dose and frequency of administration will depend on the amount and type of narcotic being antagonized. Overdoses of long-acting opioids (methadone) may require multiple IV doses of naloxone or continuous infusions. Neonates born to opioid-exposed mothers may be given IV naloxone at birth to reverse the effects of opiates.
Very few metabolism studies on naloxone have been conducted, although the major metabolite found in the urine is naloxone-3-glucuronide.121,122
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A Guide to Natural Sleep Remedies. Many of us experience the occasional night of sleeplessness without any consequences. It is when the occasional night here and there becomes a pattern of several nights in arow that you are faced with a sleeping problem. Repeated loss of sleep affects all areas of your life The physical, the mental, and theemotional. Sleep deprivation can affect your overall daily performance and may even havean effecton your personality.