New Drug Combinations

Because of the general success of the artemisinin-based anti-malarials, there have been several combinations evaluated. As mentioned previously, the artemether and lumefantrine combination has been approved. Undergoing phase III studies is a pyronaridine (Fig. 7.5) and artesunate (Fig. 7.6). Pyronaridine inhibits formation of hematin, possibly by a similar mechanism to that of chloroquine.29

Figure 7.11

pathway.

Nonmevalonate c-oh

2c-o ich3

Pyruvic Acid +

DOXP Synthase

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